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1994-10-25
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Document 2901
DOCN M94A2901
TI Neuropsychological and neurodiagnostic by imaging (MRI-SPECT) early
signs of AIDS dementia complex (ADC) in asymptomatic HIV-1 infected
subjects: follow up.
DT 9412
AU Rosci MA; Pigorini F; Bernabei A; Pau FM; Merigliano DE; Leonetti C; L.
Spallanzani Hospital for Infectious Diseases, Rome, Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):199 (abstract no. PB0226). Unique
Identifier : AIDSLINE ICA10/94369674
AB The objective of our study was to define the evolution of the early
signs of AIDS Dementia Complex, shown by neuropsychological tests, SPECT
(Single Photon Emission Computed Tomography) and MRI, at base line
observation (AIDS, Volume 6 No. 11-1992), in asymptomatic HIV-1 infected
subjects. We also aimed at defining the effect of antiretroviral therapy
on these early signs. 42 out of the 95 patients studied were reevaluated
after 6-12 months from the first visit, by psychometric tests; only 39
out of 42 have been receiving antiretroviral therapy; 29 out of 42
underwent SPECT exam also; 9 out of 42 have not been receiving any
antiretroviral therapy. Our results seem to show: a) the neurological
involvement, once the HIV-1 infection is acquired, may be precocious and
be present for a long time in a subclinical form, detectable only by
particular techniques; b) lacking correlation between mental decay
degree, shown by neuropsychological tests, presence of abnormalities at
SPECT, and immunological status (p < 0.50); c) lacking correlations
between degree of immunological impairment and evolution of neurological
involvement, shown by neuropsychological tests and SPECT (p < 0.50); d)
antiretroviral treatment induce improvement in SPECT picture and in
performance at psychometric tests not in all patients and independently
of immunological conditions; e) worsening of all untreated subjects in
spite of their persisting good immunological status (CD4+ cells >
500/mmc) in SPECT imaging.
DE Acquired Immunodeficiency Syndrome/DRUG THERAPY Antiviral
Agents/THERAPEUTIC USE AIDS Dementia Complex/*DIAGNOSIS/PSYCHOLOGY
Follow-Up Studies Human *HIV-1 Magnetic Resonance Imaging Neurologic
Examination Neuropsychological Tests Tomography, Emission-Computed,
Single-Photon MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).